all disease begins in the gut

About - The Good GutNutritionDoes all the disease begin in your Gut? The Surprising Truth Over 2,000 years ago, Hippocrates — the father of modern medicine — suggested that all disease begins in the intestine. While some of your wisdoms have tested time, you may wonder if he was right in this sense. This article tells you everything you need to know about the connection between intestinal risk and disease. Although Hippocrates was not correct to suggest that all disease begins in your intestine, the evidence shows that many chronic metabolic diseases do. Your intestinal bacteria and the integrity of your intestinal lining strongly affect your health. () According to numerous studies, undesirable bacterial products called endotoxins can sometimes be filtered through their intestinal coating and enter their bloodstream (). Their immune system then recognizes these foreign molecules and attacks them— resulting in chronic inflammation (). Some hypothesis that this induced inflammation of the diet can trigger insulin and — driving factors for diabetes and type 2 obesity, respectively. It is also believed to cause liver fat disease. At least, inflammation has been strongly linked to many of the most serious conditions in the world (, , ).However, keep in mind that this area of research is rapidly developing, and current theories can be restructured in the future. ABSTRACT Although not all disease begins in the intestine, many chronic metabolic conditions are hypothesized to be caused or influenced by chronic intestinal inflammation. Although not all disease begins in the intestine, many chronic metabolic conditions are hypothesized to be caused or influenced by chronic intestinal inflammation. Inflammation is the response of your immune system to foreign invaders, toxins, or cellular injury. Its purpose is to help your body attack these unwanted invaders and begin repairing damaged structures. Acute (short-term) inflammation, such as after a failure or injury bite, is generally considered a good thing. Without it, pathogens such as bacteria and viruses could easily take your body, causing disease or even death. However, another type of inflammation—called chronic, low-grade or systemic inflammation—can be harmful, as it is long-term, may affect your entire body, and inappropriately attacks your body's cells (, ).For example, your blood vessels — such as your coronary arteries — may be inflated, as well as structures in your brain (, ).Cryntal and systemic inflammation is believed to be one of the leading world. These include obesity, heart disease, type 2 diabetes, metabolic syndrome, Alzheimer's disease, depression, and many others (, , , , , , ).However, the exact causes of chronic inflammation are currently unknown. ABSTRACT Inflammation is the response of your immune system to foreign invaders, toxins, and cellular injuries. It is believed that chronic inflammation—which involves your entire body— leads many serious illnesses. Inflammation is the response of your immune system to foreign invaders, toxins and cellular injuries. It is believed that chronic inflammation—which involves your entire body— leads many serious illnesses. Your intestines host trillions of bacteria — collectively known as your intestinal flora (). While some of these bacteria are beneficial, others are not. As a result, the number and composition of intestinal bacteria can greatly affect their physical and mental health (). The cell walls of some of its intestinal bacteria, called gram-negative bacteria, contain lipolysaccharides (LPS), large molecules also known as endotoxins (, ).These substances can cause an immune reaction in animals. During an acute bacterial infection, they can lead to fever, depression, muscle aches and even septic shock (). In addition, these substances may sometimes filter from the intestine to the bloodstream — either constantly or just after meals (, ).Endotoxins may be carried to their blood circulation along with dietary fat, or may filter beyond the narrow unions that are supposed to prevent unwanted substances from crossing with the intestinal lining (, ). Although their amounts are too small to cause symptoms of an infection such as fever, they are high enough to stimulate chronic inflammation, causing problems with time (, ).Therefore, the increase in intestinal permeability — or leaking guts — can be the key mechanism behind chronic inflammation induced by the diet. When endotoxin levels in your blood increase to levels that are 2-3 times higher than normal, this condition is known as metabolic endotoxemia (). ABSTRACT Some bacteria in the intestine contain cell wall components called lipolysaccharides (LPS), or endotoxins. These can leak into your body and trigger inflammation. Some bacteria in the intestine contain cell wall components called lipolysaccharides (LPS), or endotoxins. These can leak into your body and trigger inflammation. Many endotoxemia studies inject endotoxins into the bloodstream of test and human animals, which has been shown to cause a rapid appearance of insulin resistance, a key characteristic of metabolic syndrome and type 2 diabetes (). It also leads to an immediate increase in inflammatory markers, indicating that an inflammatory response has been activated (). In addition, both animal and human research indicate that an unhealthy diet can cause high endotoxin levels. Animal studies suggest that a long-term diet, high in fat can cause endotoxemia, as well as inflammation, insulin resistance, obesity and metabolic disease as a result (, , ).Similarly, in a 1 month human study in 8 healthy people, a typical western diet leads to an increase of 71% in blood endotoxine levels, while the levels decreased by 31% Numerous other human studies also observed that endotoxin levels increased after a unhealthy meal, including pure cream, as well as high fat and moderate fat foods (, , , , , ). However, as most of the diets or high-fat foods also contained refined carbohydrates and processed ingredients, these results should not generalize to a healthy fat, based on real foods. Some researchers believe that refined carbohydrates increase endotoxin-producing bacteria, as well as intestinal permeability, amplifying endotoxin exposure (). A long-term study of monkeys with a refined high diet supports this hypothesis (). Gluten can also increase intestinal permeability due to its effects on the zonulin signaling molecule (, ).The exact dietary causes of endotoxemia are currently unknown. In fact, several factors are likely at stake: involving dietary components, setting up intestinal bacteria and many other factors. ABSTRACT Studies in both animals and humans show that an unhealthy diet can raise endotoxin levels in your blood — possibly leading metabolic diseases. Studies in both animals and humans show that an unhealthy diet can raise endotoxin levels in your blood — possibly leading metabolic diseases. Many chronic metabolic diseases are believed to begin in the intestine, and long-term inflammation is believed to be a driving force. The inflammation caused by bacterial endotoxins can be the missing link between an unhealthy diet, obesity and chronic metabolic diseases. However, chronic inflammation is incredibly complex, and scientists are beginning to explore how inflammation and diet can be connected. General health of your diet and lifestyle is likely to affect your risk of chronic inflammation and conditions linked to it, rather than a single dietary cause. Therefore, to keep yourself and your healthy gut, it is better to focus on a healthy global lifestyle with a lot of exercise, and a diet based on real foods, a lot of prebiotic fiber and a few processed junk foods. Read this now.

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